Veterinary Pharmacology and Therapeutics – Jim E. Riviere, Mark G. Papich

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Provides current, detailed information on using drug therapies in all major domestic animal species Organized logically by drug class and treatment indication, with exhaustive information on the rational use of drugs in veterinary medicine Includes extensive tables of pharmacokinetic data, products available, and dosage regimens Adds new chapters on pharmaceutics, ophthalmic pharmacology, food animal pharmacology, and aquatic animal pharmacology Includes access to a companion website with the figures from the book in PowerPoint   ABOUT THE AUTHOR The editors Jim E. Riviere, DVM, PhD, DSc (hon), ATS,  is The MacDonald Chair in Veterinary Medicine, University Distinguished Professor, Kansas Bioscience Eminent Scholar, and Director, Institute of Computational Comparative Medicine at Kansas State University in Manhattan, Kansas, USA. He is also a Distinguished Professor Emeritus at North Carolina State University in Raleigh, North Carolina, USA. Mark G. Papich, DVM, MS, Diplomate ACVCP,  has the Burroughs Wellcome Professorship in Veterinary Pharmacology and is a Professor of Clinical Pharmacology, Department of Molecular Biomedical Sciences, College of Veterinary Medicine at North Carolina State University in Raleigh, North Carolina, USA.   TABLE OF CONTENTS Contributors     xiii Preface     xix About the Companion Website     xxi Section AEI Principles of Pharmacology    1 Veterinary Pharmacology: An Introduction to the Discipline    3 Jim E. Riviere and Mark G. Papich Absorption, Distribution, Metabolism, and Elimination    8 Jim E. Riviere Pharmacokinetics    41 Jim E. Riviere Mechanism of Drug Action and Pharmacokinetics/ Pharmacodynamics Integration in Dosage Regimen Optimization for Veterinary Medicine    65 Pierre-Louis Toutain Principles of Pharmaceutics and Veterinary Dosage Forms    87 Raafat M. Fahmy and Marilyn N. Martinez Section f Drugs Acting on the Autonomic Nervous System    111 Introduction to the Autonomic Nervous Systemand Autonomic Pharmacology    113 Joshua A. Rowe, RoseM.McMurphy, Barbara J. Lutjemeier, andMichael J. Kenney Adrenergic Receptor Agonists and Antagonists    131 Rose M.McMurphy, Elizabeth G. Davis, Amy J. Rankin, Daniel A. Frese, Barbara J. Lutjemeier, and Michael J. Kenney Cholinergic Pharmacology: Autonomic Drugs    151 RoseM.McMurphy, Elizabeth G. Davis, Amy J. Rankin,Marjory A. Artzer, Barbara J. Lutjemeier, andMichael J. Kenney Section g Anesthetics and Analgesics, and Drugs Acting on the Central Nervous System    165 Introduction to Drugs Acting on the Central Nervous Systemand Principles of Anesthesiology  167 Peter J. Pascoe and Eugene P. Steffey Neuromuscular Blocking Agents   194 Diane E.Mason and Christopher L. Norkus Inhalation Anesthetics    216 Robert J. Brosnan and Eugene P. Steffey Injectable Anesthetic Agents    247 Lysa P. Posner Opioid Analgesic Drugs    281 Butch KuKanich andMark G. Papich Sedatives and Tranquilizers    324 Lysa P. Posner Local Anesthetics    369 Thomas W. Vickroy Euthanizing Agents    387 Anna Hampton Anticonvulsant Drugs    395 Mark G. Papich Drugs Affecting Animal Behavior    416 Margaret E. Gruen, Barbara L. Sherman, and Mark G. Papich Section h Autacoids and Antiinflammatory Drugs    449 Histamine, Serotonin, and their Antagonists    451 Wolfgang B¨aumer Analgesic, Antiinflammatory, Antipyretic Drugs    467 Peter Lees Section i Drugs Acting on the Cardiovascular System  501 Digitalis, Positive Inotropes, and Vasodilators    503 Clarke E. Atkins and Marisa K. Ames Antiarrhythmic Agents    537 Kathryn M. Meurs and Jim E. Riviere Section j Drugs Affecting Renal Function and Fluid–Electrolyte Balance    553 Principles of Acid–Base Balance: Fluid and Electrolyte Therapy, Blood Substitutes     555 Maya M. Scott-Garrard, Melisa Rosenthal, and Deborah T. Kochevar Diuretics and Renal Pharmacology    593 Butch Kukanich and Deborah T. Kochevar Section k Drugs Acting on Blood and Blood Elements    623 Anticoagulant, Antiplatelet, and Hemostatic Drugs    625 Mark G. Papich Section l Endocrine Pharmacology    647 Hypothalamic and Pituitary Hormones    649 Srujana Rayalam,Margarethe Hoenig, and Duncan C. Ferguson Hormones Affecting Reproduction    674 Wolfgang B¨aumer, C. Scott Bailey, and John Gadsby Thyroid Hormone and Antithyroid Drugs    691 Duncan C. Ferguson Glucocorticoids, Mineralocorticoids, and Adrenolytic Drugs    729 Duncan C. Ferguson and Margarethe Hoenig Drugs Influencing Glucose Metabolism    763 Margarethe Hoenig Chemotherapy of Microbial Diseases    779 Antiseptics and Disinfectants    781 Megan E. Jacob Sulfonamides and Potentiated Sulfonamides    796 Mark G. Papich -Lactam Antibiotics: Penicillins, Cephalosporins, and Related Drugs    826 Mark G. Papich Tetracycline Antibiotics    858 Mark G. Papich and Jim E. Riviere Aminoglycoside Antibiotics    877 Mark G. Papich and Jim E. Riviere Chloramphenicol and Derivatives, Macrolides, Lincosamides, andMiscellaneous Antimicrobials    903 Mark G. Papich Fluoroquinolone Antimicrobial Drugs    953 Mark G. Papich Antifungal and Antiviral Drugs    988 Jennifer L. Davis and LaraMaxwell Section AEIe Chemotherapy of Parasitic Diseases   1033 Antinematodal Drugs    1035 Carlos E. Lanusse, JuanM. Sallovitz, Sergio F. Sanchez Bruni, and Luis I. Alvarez Anticestodal and Antitrematodal Drugs    1081 Carlos E. Lanusse, Luis I. Alvarez, and Guillermo L. Virkel Macrocyclic Lactones: Endectocide Compounds    1102 Carlos E. Lanusse, Fernanda A. Imperiale, and Adrian L. Lifschitz Antiprotozoan Drugs    1128 Jennifer L. Davis and Jody L. Gookin Ectoparasiticides    1166 Ronald E. Baynes Section AEIAEI Specialty Areas of Pharmacology    1189 Chemotherapy of Neoplastic Diseases    1191 Luke A.Wittenburg and Daniel L. Gustafson Immunosuppressive Drugs    1226 Mark G. Papich Drugs for Treating Gastrointestinal Diseases    1245 Mark G. Papich Dermatopharmacology: Drugs Acting Locally on the Skin    1278 Jim E. Riviere and Rosanna Marsella Drugs that Affect the Respiratory System    1302 Mark G. Papich Ophthalmic Pharmacology    1321 Alison Clode Pharmacogenomics    1332 Katrina L.Mealey Considerations for TreatingMinor Food-Producing Animals with Veterinary Pharmaceuticals    1345 Lisa A. Tell, Margaret Oeller, Tara Marmulak, and Ronette Gehring Unique Considerations Pertaining to the Use of Drugs in Food Animals    1358 Michael D. Apley Pharmacology in Aquatic Animals    1373 Ron A.Miller Zoological Pharmacology    1395 Robert P. Hunter Section AEIf Regulatory and Other Considerations    1405 The Regulation of Animal Drugs    1407 Steven D. Vaughn andMarilyn N. Martinez Veterinary Pharmacy   1427 Gigi Davidson andMark G. Papich Medication Control Programs in Performance Animals    1439 Cynthia A. Cole Pharmacovigilance    1448 John D. Baker, Susan J. Bright-Ponte, and Lee Anne M. Palmer Dosage Forms And Veterinary Feed Directives    1459 Geof Smith and Jim E. Riviere Evidence-Based Pharmacotherapy    1465 Ronette Gehring Chemical Residues In Tissues Of Food Animals    1469 Jim E. Riviere Index    1481